Shimrit Uliel-Sibony, MD: Can Patients Develop a CBD Tolerance?



With the authorization of cannabidiol (CBD; Epidiolex, GW Pharmaceuticals) in the United States in 2018, the appeal of CBD as a therapy amongst people has actually remained to expand, with the moms and dads of people with epilepsy asking for it quickly on center check outs, according to some doctors.

At the American Epilepsy Culture’s yearly conference in New Orleans, Louisiana, in December 2018, Shimrit Uliel-Sibony, MD, from the Dana-Dwek Kid’s Medical facility at Tel-Aviv Sourasky Medical Facility, and also coworkers offered information from a test of 92 people with treatment-resistant epilepsy, both grownups and also kids, that were treated with CBD. They looked for to uncover if a resistance can be created, what the price of resistance advancement was, and also if there were distinctions in between the grown-up and also pediatric people’ resistances.

Inevitably, they discovered that resistance to CBD does exist, which brought into question its lasting efficiency as an antiseizure therapy in people with epilepsy.1 Resistance was observed in 32.6% of the people, with the ordinary dosage reported being 12.6 mg/kg/day. The mean time till look of resistance was 7.3 months (variety, 1 to 24). To talk about the research study and also its searchings for even more, Uliel-Sibony rested with NeurologyLive at the meeting.

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